Events

Pre-clinical Modelling of Human Genetic Disease and Therapy

Image courtesy of Vito Antonio Baldassarro and Laura Calzà (University of Bologna, Italy)

Dates: 8-10 May 2024

Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this meeting, we will present the very latest advances in modelling human genetic disease, from rare disease, cancer and immune disorders through to genetic modifiers. We will also discuss the latest technologies and the challenges associated with generating relevant human genetic mutations in multi-modal systems, including advanced complex cellular models, model organisms and large animal models, and how genetic technologies can be applied to genome-wide screens and therapy. In addition, speakers will outline the latest strategies to model genetic mutations in cell type and tissue-specific mechanisms, in a developmental and time-dependent fashion, and in the coding and non-coding genome. Importantly, we will also discuss the latest approaches to the phenotyping of models and how to computationally align models with human disease to guide therapeutic intervention and, ultimately, translation.

Organisers

Wendy Bickmore University of Edinburgh, UK
Luke Boulter University of Edinburgh, UK
Sara Brown University of Edinburgh, UK
Pleasantine Mill University of Edinburgh, UK
Liz Patton University of Edinburgh, UK
Owen Sansom Beatson Institute of Cancer Research, Glasgow, UK

Speakers

David Adams Wellcome Sanger Institute, UK
James Amatruda Children's Hospital Los Angeles, USA
Adrian Bird University of Edinburgh, UK
Karen Blyth Beatson Institute for Cancer Research, UK
Ross Cagan University of Glasgow, UK
Ramanuj DasGupta A*STAR Genome Institute of Singapore, Singapore
James Dowling University of Toronto, Canada
Cathy Fernandes King's College London, UK
Laura Greaves Newcastle University, UK
David Gutmann Washington University School of Medicine, USA
Alberto Kornblihtt University of Buenos Aires, Argentina
Karen Liu King's College London, UK
Cecilia Lo University of Pittsburgh, USA
Cristina Lo Celso Imperial College London, UK
Malcolm MacLeod University of Edinburgh, UK
Daniel Peeper The Netherlands Cancer Institute, The Netherlands
Steven Pollard University of Edinburgh, UK
Fiona Powrie University of Oxford, UK
Jason Rihel University College London, UK
John Sayer Newcastle University, UK
Robert Semple University of Edinburgh, UK
Angelika Schnieke TUM School of Life Sciences, Technical University of Munich, Germany
Stefan Somlo Yale School of Medicine, USA
Ellen van den Bogaard Radboud University Medical Center, The Netherlands
Eckhard Wolf University of Munich, Germany
Andrew Wood University of Edinburgh, UK
Hao Zhu University of Texas, Southwestern Medical School, USA

Updated by: Pleasantine Mill